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Showing 1 to 12 of 4193 entries
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Fertility preservation during cancer treatment: clinical guidelines.

Cancer management and research

Rodriguez-Wallberg KA, Oktay K.
PMID: 24623991
Cancer Manag Res. 2014 Mar 04;6:105-17. doi: 10.2147/CMAR.S32380. eCollection 2014.

The majority of children, adolescents, and young adults diagnosed with cancer today will become long-term survivors. The threat to fertility that cancer treatments pose to young patients cannot be prevented in many cases, and thus research into methods for...

Head and neck cancer: improving outcomes with a multidisciplinary approach.

Cancer management and research

Lo Nigro C, Denaro N, Merlotti A, Merlano M.
PMID: 28860859
Cancer Manag Res. 2017 Aug 18;9:363-371. doi: 10.2147/CMAR.S115761. eCollection 2017.

For early-stage head and neck cancer (HNC), surgery (S) or radiotherapy (RT) is a standard treatment. The multidisciplinary approach, which includes multimodality treatment with S followed by RT, with or without chemotherapy (CT) or concurrent chemoradiotherapy (CRT), is required...

Lung and colorectal cancer treatment and outcomes in the Veterans Affairs health care system.

Cancer management and research

Zullig LL, Williams CD, Fortune-Britt AG.
PMID: 25609998
Cancer Manag Res. 2015 Jan 14;7:19-35. doi: 10.2147/CMAR.S75463. eCollection 2015.

Lung cancer (LC) and colorectal cancer (CRC) are the second- and third-most commonly diagnosed cancers in the Veterans Affairs (VA) health care system. While many studies have evaluated the treatment quality and outcomes of various aspects of VA LC...

Glucocorticoid receptor expression in 20 solid tumor types using immunohistochemistry assay.

Cancer management and research

Block TS, Murphy TI, Munster PN, Nguyen DP, Lynch FJ.
PMID: 28293120
Cancer Manag Res. 2017 Mar 06;9:65-72. doi: 10.2147/CMAR.S124475. eCollection 2017.

BACKGROUND: Glucocorticoid receptor (GR) activity plays a role in many aspects of human physiology and may play a crucial role in chemotherapy resistance in a wide variety of solid tumors. A novel immunohistochemistry (IHC) based assay has been previously...

Interleukin-1 receptor antagonist inhibits angiogenesis via blockage IL-1α/PI3K/NF-κβ pathway in human colon cancer cell.

Cancer management and research

Ma J, Sun X, Guo T, Su H, Chen Q, Gong Z, Qi J, Zhao X.
PMID: 29062241
Cancer Manag Res. 2017 Oct 09;9:481-493. doi: 10.2147/CMAR.S147699. eCollection 2017.

PURPOSE: This article investigates the relationship between cancer cells and stromal cells in carcinoma cell living microenvironment and elucidates the mechanism that interleukin-1 receptor antagonist (IL-1RA) blocks metastatic potential in colon cancer.METHODS: Western blot and RT-PCR assay were used...

APF530 versus ondansetron, each in a guideline-recommended three-drug regimen, for the prevention of chemotherapy-induced nausea and vomiting due to anthracycline plus cyclophosphamide-based highly emetogenic chemotherapy regimens: a post hoc subgroup analysis of the Phase III randomized MAGIC trial.

Cancer management and research

Schnadig ID, Agajanian R, Dakhil C, Gabrail N, Vacirca J, Taylor C, Wilks S, Braun E, Mosier MC, Geller RB, Schwartzberg L, Vogelzang N.
PMID: 28579832
Cancer Manag Res. 2017 May 19;9:179-187. doi: 10.2147/CMAR.S129059. eCollection 2017.

BACKGROUND: APF530, a novel extended-release granisetron injection, was superior to ondansetron in a guideline-recommended three-drug regimen in preventing delayed-phase chemotherapy-induced nausea and vomiting (CINV) among patients receiving highly emetogenic chemotherapy (HEC) in the double-blind Phase III Modified Absorption of...

Marked radiographic response of a HER-2-overexpressing biliary cancer to trastuzumab.

Cancer management and research

Sorscher S.
PMID: 24376362
Cancer Manag Res. 2013 Dec 11;9:1-3. doi: 10.2147/CMAR.S55091. eCollection 2013.

Trastuzumab is a monoclonal antibody targeting HER-2. HER-2 overexpression has been described in gallbladder cancer and in cholangiocarcinoma. This report describes the first case of a patient with HER-2 overexpressing metastatic gallbladder adenocarcinoma and responding radiographically and biochemically to...

A profile of enzalutamide for the treatment of advanced castration resistant prostate cancer.

Cancer management and research

Greasley R, Khabazhaitajer M, Rosario DJ.
PMID: 26109877
Cancer Manag Res. 2015 Jun 12;7:153-64. doi: 10.2147/CMAR.S50585. eCollection 2015.

Recent advances in understanding the mechanisms underlying the development and progression of castration resistant prostate cancer from androgen-sensitive prostate cancer have provided new avenues exploring efficacious therapies in a disease which is the second leading cause of cancer deaths...

New developments in the treatment of peripheral T-cell lymphoma - role of Belinostat.

Cancer management and research

Reimer P.
PMID: 26082661
Cancer Manag Res. 2015 Jun 03;7:145-51. doi: 10.2147/CMAR.S85351. eCollection 2015.

Peripheral T-cell lymphomas (PTCL) represent a heterogeneous group of rare malignancies that with the exception of anaplastic lymphoma kinase expressing anaplastic large cell lymphoma, share a poor outcome after standard (eg, anthracycline-based) chemotherapy. Most patients are either refractory to...

Durable response using regorafenib in an elderly patient with metastatic colorectal cancer: case report.

Cancer management and research

Tang R, Kain T, Herman J, Seery T.
PMID: 26640390
Cancer Manag Res. 2015 Nov 19;7:357-60. doi: 10.2147/CMAR.S91547. eCollection 2015.

Regorafenib, an oral multikinase inhibitor, was approved in September 2012 by the US Food and Drug Administration for the treatment of patients with metastatic colorectal cancer. Since this time, however, few case reports outlining real-world usage have been published...

Vaginal cuff brachytherapy in endometrial cancer - a technically easy treatment?.

Cancer management and research

Sabater S, Andres I, Lopez-Honrubia V, Berenguer R, Sevillano M, Jimenez-Jimenez E, Rovirosa A, Arenas M.
PMID: 28848362
Cancer Manag Res. 2017 Aug 09;9:351-362. doi: 10.2147/CMAR.S119125. eCollection 2017.

Endometrial cancer (EC) is one of the most common gynecological cancers among women in the developed countries. Vaginal cuff is the main location of relapses after a curative surgical procedure and postoperative radiation therapy have proven to diminish it....

The clinical development of obinutuzumab for the treatment of follicular lymphoma.

Cancer management and research

Ma B, Ujjani C.
PMID: 28435325
Cancer Manag Res. 2017 Apr 10;9:103-113. doi: 10.2147/CMAR.S114526. eCollection 2017.

Impressive progress has been made in recent decades for advanced-stage follicular lymphoma with the availability of anti-CD20 monoclonal antibodies, initially rituximab and more recently obinutuzumab. Obinutuzumab is a unique, third-generation, fully humanized glycoengineered IgG

Showing 1 to 12 of 4193 entries